Objective Performing a meta-analysis using Bayesian statistics to review the association between physical inactivity and circulating platelet-derived microvesicles (PMVs) andendothelial-derived microvesicles (EMVs) to promote or hinder blood vessel formation. Methods The research examined the impact of reduced physical inactivity on PMVs and EMVs production response compared to the microvesicles before being physically inactive as an intervention were selected for the analysis. Studies were identified through searches of the PubMed and Google Scholar databases. Furthermore, the process of selecting quality papers included searching reference lists of relevant studies. Study quality was assessed using the Downs and Black Checklist and Cochrane’s criteria. Results Three studies met the inclusion criteria for the meta-analysis for the systematic review. One study assessed EMPs on two different types of EMVs, thus both sets of data were included, giving 4 total trials included in the analysis. However, the change in SD in each study was not given, nor the exact t-values and SD at each time point under control, or the experimental conditions. Therefore, the meta-analysis could not be further calculated.
Conclusion Reduced physical activity increased PMV and EMV production against the lower of EMVs before the intervention. More research is needed on the topic for the correlation between reduced physical activity and microvesicle production to be fully understood.
